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KMID : 0370220210650040237
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Yakhak Hoeji
2021 Volume.65 No. 4 p.237 ~ p.245
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Antinociceptive Effects of Arachidonoyl-serotonin (AA-5-HT) by Activation of Cannabinoid Receptor and Inhibition of TRPV1
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Sym Eun-Jin
Shim Won-Sik
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Abstract
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Pain is a noxious sensation caused by tissue damage, which can severely interfere with a person’s quality oflife. Although numerous analgesics are available for eradicating pain, there remain limitations in terms of safety andefficacy. This review focuses on arachidonoyl-serotonin (AA-5-HT) ? an endogenous lipid with a putative antinociceptiveeffect. After detailed investigation, previous studies have revealed that AA-5-HT can stimulate the cannabinoid system,which results in the inhibition of pain sensation. Moreover, AA-5-HT can inhibit the action of TRPV1, which is a nonselectivecation channel that mediates pain signals in the nervous system. This dual effect makes AA-5-HT a potentiallysafe and potent analgesic. This review summarizes the roles of the cannabinoid system and TRPV1 in pain sensation, andthe function of AA-5-HT in pain modulation.
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KEYWORD
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GPR119 agonists, Antidiabetic agents, Fragment structure, Bioequivalent, Pyridazine analogs, Lead compounds
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Listed journal information
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